Synthesis of biologically active compounds based on 2-ferrocenylmethylene-3-quinuclidone
- Cite this article as:
- Klimova, E.I., Ruiz Ramirez, L., Martinez Garcia, M. et al. Russ Chem Bull (1996) 45: 2602. doi:10.1007/BF01431126
Biologically active nitrogen heterocycles (1–7) containing ferrocene and quinuclidine fragments were synthesized. 3-Methylene-2-ferrocenylmethylenequinuiclidine forms adducts withN-phenylimides of azodicarboxylic (the structure was established by X-ray structural analysis) and malefic acids. 3-Methylene-2-fer-rocenylmethylenequinticlidine also undergoes [4+2]-cyclodimerization when heated and adds salts of the 3-methyl-2-ferrocenylmethyleneI-azoniabicyclo[2.2.2]oct-3-yl cation at the terminal methylene group to form a linear addition product.