Protoplasma

, Volume 209, Issue 1, pp 9–18

The ins and outs of yeast vacuole trafficking

  • M. Götte
  • T. Lazar
Focus on Cellular Biochemistry

DOI: 10.1007/BF01415696

Cite this article as:
Götte, M. & Lazar, T. Protoplasma (1999) 209: 9. doi:10.1007/BF01415696

Summary

Vacuoles are ubiquitous organelles in the fungal and plant kingdoms. They serve a variety of functions and are important for cell homeostasis. A constant turnover of proteins and membranes makes vacuoles dynamic organelles. Various transport pathways share the vacuole as their joint destination. The trafficking pathways are regulated independently. In yeast cells many components of the protein and membrane transport machinery are known. Recent years have seen much progress in our understanding of the protein-sorting pathways and the biogenesis of this organelle. Improvements of our understanding of the vesicular transport pathways and vacuolar membrane fusion are reviewed.

Keywords

YeastVacuoleTransport vesiclesMembrane fusionVacuolar-morphology mutantVacuolar-protein-sorting mutant

Abbreviations

ALP

alkaline phosphatase

AP

adaptor protein complex

CPY

carboxypeptidase Y

CPS

carboxypeptidase S

NSF

N-ethylmaleimide-sensitive membrane fusion protein

PIP

phos-phatidyl inositol phosphate

PVC

prevacuolar compartment

SNAP

soluble N-ethylmaleimide-sensitive factor attachment protein

SNARE SNAP

receptor

TGN

trans-Golgi network

vam

vacuolar morphology (mutant)

vps

vacuolar protein sorting (mutant)

Copyright information

© Springer-Verlag 1999

Authors and Affiliations

  • M. Götte
    • 1
  • T. Lazar
    • 1
  1. 1.Molekulare GenetikMax-Planck-Institut für Biophysikalische ChemieGöttingenFederal Republic of Germany
  2. 2.Children's HospitalHarvard Medical SchoolBostonUSA