Acta Neurochirurgica

, Volume 118, Issue 3, pp 130–136

A primate model for acute and late cerebral vasospasm: Angiographic findings


  • T. J. Delgado-Zygmunt
    • Neurosurgical Research DepartmentUniversity Hospital
  • M. A. -R. Arbab
    • Neurosurgical Research DepartmentUniversity Hospital
  • Y. Shiokawa
    • Neurosurgical DepartmentKarolinska Sjukhuset
  • N. -A. Svendgaard
    • Neurosurgical DepartmentKarolinska Sjukhuset
Experimental Research

DOI: 10.1007/BF01401298

Cite this article as:
Delgado-Zygmunt, T.J., Arbab, M.A.-., Shiokawa, Y. et al. Acta neurochir (1992) 118: 130. doi:10.1007/BF01401298


A subarachnoid haemorrhage (SAH) in the squirrel monkey was produced by injection of blood via a permanently implanted catheter connected to the cisterna magna and a cannula stereotactically inserted into the interpeduncular cistern. Repeated angiographic examinations of the vertebro-basilar and right internal carotid arteries revealed a biphasic vasospasm with a maximal acute spasm at ten minutes and maximal late spasm at six days after blood injection. The present study has shown that a reproducible biphasic vasospasm can be produced in the squirrel monkey and evaluated by repeated angiographic examinations. The model is suitable in the study of basic mechanisms underlying vasospasm in a primate and, due to the size of the animal, autoradiographic evaluation of the cerebral blood flow and metabolism can be performed at an acceptable cost.


Angiographysquirrel monkeysubarachnoid haemorrhagevasospasm

Copyright information

© Springer-Verlag 1992