Amino Acids

, Volume 17, Issue 3, pp 315–322

Urine glycyl-L-proline increase and skin trophicity

  • J. Le
  • C. Perier
  • S. Peyroche
  • F. Rascle
  • M. A. Blanchon
  • R. Gonthier
  • J. Frey
  • A. Chamson
Short Communication

DOI: 10.1007/BF01366930

Cite this article as:
Le, J., Perier, C., Peyroche, S. et al. Amino Acids (1999) 17: 315. doi:10.1007/BF01366930

Summary

Glycyl-L-proline (gly-pro) is an end product of collagen metabolism that is further cleaved by prolidase (EC 3.4.13.9); the resulting proline molecules are recycled into collagen or other proteins. We postulated a relationship between defective gly-pro hydrolysis, increased collagen degradation and skin destruction. This relationship was tested using HPLC to measure the gly-pro in urine. 24 hour urine samples were collected from 27 old people (86 ± 6 years old), of whom 15 were suffering from skin pressure sores of the sacrum or calcaneus. The urine from patients with pressure sores contained significantly more gly-pro than the urine from the control. A cut-off at 7μmol/ mmol creatinine gave the test a positive predictive value of 70%. Collagen breakdown was also increased as indicated by the increase of hydroxyproline (hyp) in the urine. But this breakdown seemed to stop at the gly-pro step.

Keywords

Amino acidsGlycyl-L-prolineUrineTrophicityCollagen

Copyright information

© Springer-Verlag 1999

Authors and Affiliations

  • J. Le
    • 1
  • C. Perier
    • 1
  • S. Peyroche
    • 1
  • F. Rascle
    • 1
  • M. A. Blanchon
    • 1
  • R. Gonthier
    • 1
  • J. Frey
    • 1
  • A. Chamson
    • 1
  1. 1.Laboratoire de BiochimieFaculté de MédecineSaint-Etienne Cedex 2France