Calcified Tissue International

, Volume 53, Issue 5, pp 362–364

Interleukin-11 inhibits bone formation in vitro


  • Francis J. Hughes
    • Department of Oral Medicine and PeriodontologyThe London Hospital Medical College
  • Gareth L. Howells
    • Department of Oral PathologyThe London Hospital Medical College
Rapid Communication

DOI: 10.1007/BF01351844

Cite this article as:
Hughes, F.J. & Howells, G.L. Calcif Tissue Int (1993) 53: 362. doi:10.1007/BF01351844


The effects of interleukin-11(IL-11) on the differentiation of osteoblast precursors was tested using a bone nodule forming assay in rat calvaria cell cultures. IL-11 caused a dose dependent inhibition of nodule formation, with 500U/ml IL-11 resulting in complete inhibition of nodule formation. IL-11 also caused a reduction in alkaline phosphatase expression in these cultures. These effects are similar to, but more potent than, the actions of IL-6 on these cells. These results indicate that IL-11 is an osteotropic cytokine and suggest that IL-11 may be an important inhibitor of bone formation in health and disease.

Copyright information

© Springer-Verlag New York Inc. 1993