Digestive Diseases and Sciences

, Volume 29, Issue 7, pp 614–619

Chronic idiopathic ulcerative colitis

Pregnancy and fetal outcome
  • Robert R. Schade
  • David H. Van Thiel
  • Judith S. Gavaler
Original Articles

DOI: 10.1007/BF01347293

Cite this article as:
Schade, R.R., Van Thiel, D.H. & Gavaler, J.S. Digest Dis Sci (1984) 29: 614. doi:10.1007/BF01347293

Abstract

Many frequently cited studies of the interaction of chronic idiopathic ulcerative colitis (CIUC) and pregnancy were performed in the 1950s before pharmacotherapy for this disease was common. We retrospectively reviewed obstetrical records at a large maternity facility to determine the effects of CIUC on pregnancy and on fetal outcome. We observed that the prevalence of CIUC in pregnant women was below that expected based on published data (P<0.01). The use of prednisone and sulfasalazine in pregnant women with CIUC was common; 85% of these patients received these medications. We found significantly greater (P<0.01) incidence of low-birth-weight in infants (<2500 g) of mothers with CIUC than in the control population. The delivery of infants of low birth weight occurred despite adequate maternal weight gain.

Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • Robert R. Schade
    • 1
  • David H. Van Thiel
    • 1
  • Judith S. Gavaler
    • 1
  1. 1.Department of MedicineUniversity of Pittsburgh, School of MedicinePittsburgh