Archives of Virology

, Volume 136, Issue 3, pp 439–446

Influenza A virus replication is inhibited by tumor necrosis factor-α in vitro

  • H. Van Campen
Brief Report

DOI: 10.1007/BF01321073

Cite this article as:
Van Campen, H. Archives of Virology (1994) 136: 439. doi:10.1007/BF01321073


Treatment of Madin-Darby canine kidney (MDCK) cells with ≥ 10 ng/ml of recombinant murine tumor necrosis factor-α (rm TNF-α) prior to inoculation with influenza A/PR/8/34, (H1N1), resulted in decreased production of infectious virus as determined by plaque assay, inhibition of viral protein synthesis and a reduction in cytopathic effect. The inhibition of viral replication in vitro suggests a role for TNF-α in the host's defense against influenza A virus infections.

Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • H. Van Campen
    • 1
  1. 1.Department of Veterinary ScienceThe Pennsylvania State UniversityUSA
  2. 2.Department of Veterinary SciencesUniversity of WyomingUSA