Influenza A virus replication is inhibited by tumor necrosis factor-α in vitro
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- Van Campen, H. Archives of Virology (1994) 136: 439. doi:10.1007/BF01321073
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Treatment of Madin-Darby canine kidney (MDCK) cells with ≥ 10 ng/ml of recombinant murine tumor necrosis factor-α (rm TNF-α) prior to inoculation with influenza A/PR/8/34, (H1N1), resulted in decreased production of infectious virus as determined by plaque assay, inhibition of viral protein synthesis and a reduction in cytopathic effect. The inhibition of viral replication in vitro suggests a role for TNF-α in the host's defense against influenza A virus infections.