Archives of Virology

, Volume 98, Issue 1, pp 51–64

Human Cytomegalovirus morphogenesis: an ultrastructural study of the late cytoplasmic phases


  • B. Severi
    • Institute of Clinical Electron MicroscopyUniversity of Bologna
  • M. P. Landini
    • Institute of MicrobiologyUniversity of Bologna
  • E. Govoni
    • Institute of Clinical Electron MicroscopyUniversity of Bologna
Original Papers

DOI: 10.1007/BF01321005

Cite this article as:
Severi, B., Landini, M.P. & Govoni, E. Archives of Virology (1988) 98: 51. doi:10.1007/BF01321005


The late cytoplasmic phases of human Cytomegalovirus (HCMV) morphogenesis in cultured fibroblasts have been studied by transmission electron microscopy focusing attention on the relationship between the viral particles and host cell organelles. The results obtained largely reflect changes in cells subjected to sublethal injurious stimuli induced by many viruses as well as different noxious agents. A great increase in the number of Golgi apparatuses and lysosomes was observed, both of them interacting with the viral progeny. HCMV seems to acquire its final envelope from Golgi-derived structures and, less frequently, from the plasma membrane.

Copyright information

© Springer-Verlag 1988