Original Papers

Archives of Virology

, Volume 98, Issue 1, pp 51-64

First online:

Human Cytomegalovirus morphogenesis: an ultrastructural study of the late cytoplasmic phases

  • B. SeveriAffiliated withInstitute of Clinical Electron Microscopy, University of Bologna
  • , M. P. LandiniAffiliated withInstitute of Microbiology, University of Bologna
  • , E. GovoniAffiliated withInstitute of Clinical Electron Microscopy, University of Bologna

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The late cytoplasmic phases of human Cytomegalovirus (HCMV) morphogenesis in cultured fibroblasts have been studied by transmission electron microscopy focusing attention on the relationship between the viral particles and host cell organelles. The results obtained largely reflect changes in cells subjected to sublethal injurious stimuli induced by many viruses as well as different noxious agents. A great increase in the number of Golgi apparatuses and lysosomes was observed, both of them interacting with the viral progeny. HCMV seems to acquire its final envelope from Golgi-derived structures and, less frequently, from the plasma membrane.