Amino Acids

, Volume 15, Issue 3, pp 263–269

Free D- and L-amino acids in ventricular cerebrospinal fluid from Alzheimer and normal subjects

Authors

  • G. Fisher
    • Department of ChemistryBarry University
  • N. Lorenzo
    • Department of ChemistryBarry University
  • H. Abe
    • Laboratory of Marine Biochemistry, Graduate School of Agricultural Life ScienceThe University of Tokyo
  • E. Fujita
    • Department of Food Science and NutritionKyoritsu Women's University
  • W. H. Frey
    • Alzheimer's Treatment and Research CenterHealth Partners Foundation, St. Paul
  • C. Emory
    • Alzheimer's Treatment and Research CenterHealth Partners Foundation, St. Paul
  • M. M. Di Fiore
    • Department of Life ScienceSecond University of Naples
  • A. D'Aniello
    • Department of Biochemistry and Molecular BiologyStazione Zoologica “A Dohrn”
Full Papers

DOI: 10.1007/BF01318865

Cite this article as:
Fisher, G., Lorenzo, N., Abe, H. et al. Amino Acids (1998) 15: 263. doi:10.1007/BF01318865

Summary

Free D-Ser, D-Asp and total D-amino acids were significantly higher (p < 0.05) in Alzheimer (AD) ventricular CSF than in normal CSF. There was no significant difference in the total L-amino acids between AD and normal CSF, but L-Gln and L-His were significantly higher (p < 0.05) in ADCSF. The higher concentrations of these D- and L-amino acids in AD ventricular CSF could reflect the degenerative process that occurs in Alzheimer's brain since ventricular CSF is the repository of amino acids from the brain.

Keywords

D- and L-Amino acidsCerebrospinal fluidVentricular CSFAlzheimer's disease

Copyright information

© Springer-Verlag 1998