Free D- and L-amino acids in ventricular cerebrospinal fluid from Alzheimer and normal subjects
- Cite this article as:
- Fisher, G., Lorenzo, N., Abe, H. et al. Amino Acids (1998) 15: 263. doi:10.1007/BF01318865
Free D-Ser, D-Asp and total D-amino acids were significantly higher (p < 0.05) in Alzheimer (AD) ventricular CSF than in normal CSF. There was no significant difference in the total L-amino acids between AD and normal CSF, but L-Gln and L-His were significantly higher (p < 0.05) in ADCSF. The higher concentrations of these D- and L-amino acids in AD ventricular CSF could reflect the degenerative process that occurs in Alzheimer's brain since ventricular CSF is the repository of amino acids from the brain.