Digestive Diseases and Sciences

, Volume 38, Issue 4, pp 577–593

Interferon in the management of chronic hepatitis B

  • Robert P. Perrillo
Review Article

DOI: 10.1007/BF01316785

Cite this article as:
Perrillo, R.P. Digest Dis Sci (1993) 38: 577. doi:10.1007/BF01316785

Abstract

Many drugs have been used in the treatment of chronic hepatitis B, but with the exception of interferon, none have proved to be effective. Several studies have found that a sustained loss of viral replication occurs in approximately 40% of patients who arted with a 16-week course of recombinant interferon alfa-2b given in a dose of 5 million units daily or 10 million units three times weekly. Moreover, disappearance of hepatitis B surface antigen in serum has been observed in 10–15% of treated patients. Based on these results, the Food and Drug Administration approved the use of this form of interferon in chronic hepatitis B in July 1992. This article reviews the importance of chronic hepatitis B as a health problem as well as the mechanisms of action, benefits, and adverse effects associated with interferon. Particular emphasis is given to the safety and efficacy data for recombinant interferon alfa-2b.

Key Words

interferonantiviralhepatitis Bhepatitis B virus

Copyright information

© Plenum Publishing Corporation 1993

Authors and Affiliations

  • Robert P. Perrillo
    • 2
    • 1
  1. 1.Washington University School of MedicineWashingtonUSA
  2. 2.Gastroenterology SectionSt. Louis Veterans Affairs Medical Center (111 JC)Saint Louis