Archives of Virology

, Volume 104, Issue 3, pp 351–355

Non-A, non-B hepatitis: visualization of virus-like particles from chimpanzee and human sera

  • Kenji Abe
  • Takeshi Kurata
  • Toshio Shikata
Rapid Communication

DOI: 10.1007/BF01315557

Cite this article as:
Abe, K., Kurata, T. & Shikata, T. Archives of Virology (1989) 104: 351. doi:10.1007/BF01315557

Summary

Virus-like particles (VLP), morphologically similar to togavirus particles, were detected in the sera of chimpanzees and humans with chronic non-A, non-B (NANB) hepatitis. Particles resembling the virus were also found in the cytoplasm of hepatocytes obtained from NANB hepatits infected chimpanzees. Furthermore, two chimpanzees inoculated with materials containing the VLP developed NANB hepatitis. These results strongly suggest that the VLP may be closely associated with the agent of NANB hepatitis.

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • Kenji Abe
    • 1
  • Takeshi Kurata
    • 1
  • Toshio Shikata
    • 2
  1. 1.Department of PathologyNational Institute of HealthTokyoJapan
  2. 2.Department of PathologyNihon University School of MedicineTokyoJapan

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