Non-A, non-B hepatitis: visualization of virus-like particles from chimpanzee and human sera
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- Abe, K., Kurata, T. & Shikata, T. Archives of Virology (1989) 104: 351. doi:10.1007/BF01315557
Virus-like particles (VLP), morphologically similar to togavirus particles, were detected in the sera of chimpanzees and humans with chronic non-A, non-B (NANB) hepatitis. Particles resembling the virus were also found in the cytoplasm of hepatocytes obtained from NANB hepatits infected chimpanzees. Furthermore, two chimpanzees inoculated with materials containing the VLP developed NANB hepatitis. These results strongly suggest that the VLP may be closely associated with the agent of NANB hepatitis.