Rapid Communication

Archives of Virology

, Volume 104, Issue 3, pp 351-355

First online:

Non-A, non-B hepatitis: visualization of virus-like particles from chimpanzee and human sera

  • Kenji AbeAffiliated withDepartment of Pathology, National Institute of Health
  • , Takeshi KurataAffiliated withDepartment of Pathology, National Institute of Health
  • , Toshio ShikataAffiliated withDepartment of Pathology, Nihon University School of Medicine

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Virus-like particles (VLP), morphologically similar to togavirus particles, were detected in the sera of chimpanzees and humans with chronic non-A, non-B (NANB) hepatitis. Particles resembling the virus were also found in the cytoplasm of hepatocytes obtained from NANB hepatits infected chimpanzees. Furthermore, two chimpanzees inoculated with materials containing the VLP developed NANB hepatitis. These results strongly suggest that the VLP may be closely associated with the agent of NANB hepatitis.