The preferential cytotoxicity of reovirus for certain transformed cell lines
Purchase on Springer.com
$39.95 / €34.95 / £29.95*
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.
The susceptibility of a variety of cell lines of different mammalian origin to cytotoxic (CT) induction by either ultraviolet light-irradiated reovirus type 2 (UVR2) or viable reovirus type 2 plus the protein synthesis inhibitor, cycloheximide, was examined. The following groups of cells were found to be susceptible to CT-induction: certain tumor cells and spontaneously transformed cell lines of human origin and certain virally and spontaneously transformed cell lines of murine origin. The following groups of cells were found to be resistant: normal human diploid cell lines, primary and continuous cell cultures of subhuman primates, primary mouse cells, normal rat kidney cells and baby hamster kidney cells. Susceptibility to CT-induction could not be related to the adsorption of virus to cells, nor to the capacity of the cell to support virus replication.
- Borsa, J., Graham, A. F.: Reovirus: RNA polymerase activity in purified virions. Biochem. biophys. Res. Commun.33, 895–901 (1968).
- Hand, R., Tamm, I.: Reovirus: Effect of noninfective viral components on cellular deoxyribonucleic acid synthesis. J. Virol.11, 223–231 (1973).
- Lai, M. T., Joklik, W.: The induction of interferon by temperature-sensitive mutants of reovirus, UV-irradiated reovirus, and subviral reovirus particles. Virology51, 191–204 (1973).
- Lai, M. T., Wérenne, J. J., Joklik, W.: The preparation of reovirus top component and its effect on host DNA and protein synthesis. Virology54, 237–244 (1973).
- Loh, P. C., Crowley, J.: Reovirus type 2 infection, cycloheximide and cell death. Proc. Soc. exp. Biol. Med.125, 1287–1290 (1969).
- Loh, P. C., Oie, H. K.: Growth characteristics of reovirus type 2: Ultraviolet light inactivated virion preparations and cell death. Arch. ges. Virusforsch.26, 197–208 (1969).
- Loh, P. C., Oie, H. K., Camyre, K. P.: Role of lysine in the replication of reovirus II. Characterization of empties and effect on macromolecular synthesis. Arch. ges. Virusforsch.35, 114–125 (1971).
- Loh, P. C., Oie, H. K., Ratnayake, R. M.: Accelerated cytopathology in HeLa cells induced by reovirus and cycloheximide. Infect. Immun.2, 705–712 (1970).
- Loh, P. C., Shatkin, A. J.: Structural proteins of reovirus. J. Virol.2, 1353–1359 (1968).
- Shatkin, A. J., Sipe, J. D.: RNA polymerase activity in purified reoviruses. Proc. Natl. Acad. Sci. U.S.A.61, 1462–1469 (1968).
- Shaw, J. E., Cox, D. C.: Early inhibition of cellular DNA synthesis by high multiplicities of infections and UV-inactivated reovirus. J. Virol.12, 704–710 (1973).
- Subashinghe, H. A., Loh, P. C.: Reovirus cytotoxicity: some properties of the UV-irradiated reovirus and its capsid proteins. Arch. ges. Virusforsch.39, 172 to 189 (1972).
- Watanabe, Y., Kudo, H., Graham, A. F.: Selective inhibition of reovirus ribonucleic acid synthesis by cycloheximide. J. Virol.1, 36–44 (1967).
- The preferential cytotoxicity of reovirus for certain transformed cell lines
Archives of Virology
Volume 54, Issue 4 , pp 307-315
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Industry Sectors