Archives of Virology

, Volume 66, Issue 3, pp 215–226

Astrovirus-like, coronavirus-like, and parvovirus-like particles detected in the diarrheal stools of beagle pups

  • F. P. WilliamsJr.
Original Papers

DOI: 10.1007/BF01314735

Cite this article as:
Williams, F.P. Archives of Virology (1980) 66: 215. doi:10.1007/BF01314735


Astrovirus-like, coronavirus-like, and parvovirus-like particles were detected through electron microscopic (EM) examination of loose and diarrheal stools from a litter of beagle pups. Banding patterns obtained from equilibrium centrifugations in CsCl supported the EM identification. Densities associated with the identified particles were: 1.34 g/ml for astrovirus, 1.39 g/ml for “full” parvovirus, and 1.24–1.26 g/ml for “typical” coronavirus. Convalescent sera from the pups aggregated these three particle types as observed by immunoelectron microscopy (IEM). Only coronavirus-like particles were later detected in formed stools from these same pups. Coronavirus and parvo-like viruses are recognized agents of canine viral enteritis, however, astrovirus has not been previously reported in dogs.

Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • F. P. WilliamsJr.
    • 1
  1. 1.Health Effects Research LaboratoryU.S. Environmental Protection AgencyCincinnatiUSA

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