Original Articles

Digestive Diseases and Sciences

, Volume 24, Issue 9, pp 684-688

First online:

Malignancy in a 19-year experience of adult celiac disease

  • W. S. SelbyAffiliated withA. W. Morrow Department of Gastroenterology, Royal Prince Alfred Hospital
  • , N. D. GallagherAffiliated withA. W. Morrow Department of Gastroenterology, Royal Prince Alfred Hospital

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Abstract

Malignancy has developed in 10 of 93 patients with celiac disease who attended this hospital from 1959 to 1978. Four patients developed lymphoma, 5 a squamous carcinoma of the esophagus, and 1 an adenocarcinoma of the ileum. Because the majority of patients were ingesting varying amounts of gluten at the time of their follow-up no conclusion can be drawn about the possible role of a gluten-free diet in the prevention of malignancy.