Digestive Diseases and Sciences

, Volume 30, Issue 12, pp 1161–1165

Modulation of human colonic arachidonic acid metabolism by sulfasalazine

  • C. J. Hawkey
  • N. K. Boughton-Smith
  • B. J. R. Whittle
Original Articles

DOI: 10.1007/BF01314051

Cite this article as:
Hawkey, C.J., Boughton-Smith, N.K. & Whittle, B.J.R. Digest Dis Sci (1985) 30: 1161. doi:10.1007/BF01314051

Abstract

The effects of sulfasalazine and its moieties on synthesis of individual products of arachidonic acid metabolism by human colonic mucosa have been investigated. Sulfasalazine inhibited synthesis of the lipoxygenase products. Sulfasalazine and sulfapyridine also inhibited synthesis of thromboxane B2 while enhancing synthesis of prostaglandin (PG) F or PGE2, respectively. Inhibition of synthesis of lipoxygenase products and modulation of the profile of cyclooxygenase products could reduce inflammation and enhance mucosal resistance to damage in ulcerative colitis.

Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • C. J. Hawkey
    • 1
    • 2
  • N. K. Boughton-Smith
    • 1
    • 2
  • B. J. R. Whittle
    • 1
    • 2
  1. 1.Department of TherapeuticsUniversity HospitalNottinghamEngland
  2. 2.Department of Prostaglandin ResearchWellcome Research Laboratories, Langley CourtBeckenhamUK