Digestive Diseases and Sciences

, Volume 37, Issue 1, pp 1–9

Hepatitis B virus

New and evolving issues
  • Boris Yoffe
  • Christine A. Noonan
Review Article

DOI: 10.1007/BF01308334

Cite this article as:
Yoffe, B. & Noonan, C.A. Digest Dis Sci (1992) 37: 1. doi:10.1007/BF01308334


Recent developments in molecular biology have advanced our understanding of the pathogenesis of HBV-induced disease. New data derived from the molecular analysis of clinical material have begun to bridge the gap between bench research and the clinical arena. In this review, we consider topics that have relevance to clinical management and that have not been summarized in the recent literature. The recent advances that have been made in the areas of HBV variants,in vitro cell culture systems, and extrahepatic infection are discussed in greater detail.

Key Words

hepatitis B virusHBV variantsHBV culture systemsliver transplantationextrahepatic infection

Copyright information

© Plenum Publishing Corporation 1992

Authors and Affiliations

  • Boris Yoffe
    • 1
  • Christine A. Noonan
    • 1
  1. 1.Veterans Affairs Medical Center and Departments of Medicine and Molecular VirologyBaylor College of MedicineHouston
  2. 2.Division of Digestive DiseasesVAMCHouston