Digestive Diseases and Sciences

, Volume 37, Issue 2, pp 262–267

Gallbladder hypokinesia and normal gastric emptying of liquids in patients with dyspeptic symptoms

A double-blind placebo-controlled clinical trial with cisapride
  • Leonardo Marzio
  • Franca DiFelice
  • Maria Grazia Laico
  • Bruno Imbimbo
  • Domenico Lapenna
  • Franco Cuccurullo
Original Articles

DOI: 10.1007/BF01308181

Cite this article as:
Marzio, L., DiFelice, F., Laico, M.G. et al. Digest Dis Sci (1992) 37: 262. doi:10.1007/BF01308181

Abstract

Gastric and gallbladder emptying after a standard liquid meal were studied in 65 patients with early satiety, bloating, pain at the right hypochondrium or the epigastrium, nausea, and occasionally vomiting. Fifty normal subjects were studied as a control group. Gastric and gallbladder emptying were evaluated by means of real-time ultrasonography (RUS). Serial RUS scans were made after a 12-hr fast and every 15 min after a standard meal for 2 hr. Patients were considered to have delayed gastric emptying or hypokinetic gallbladder when gastric diameters and gallbladder volume evaluated 45 min after meal were 2sd above the corresponding mean values of the normal subject group. Fifteen patients (23%) were found with delayed gastric emptying and 20 (30.7%) a reduced gallbladder emptying. None of our patients showed delayed gastric emptying and hypokinetic gallbladder simultaneously. The 20 patients with reduced gallbladder emptying were included in a double-blind randomized, placebo controlled, change-over study with cisapride (10 mg three times a day) for 30 days. Cisapride treatment reversed the gallbladder hypomotility within the normal range while placebo did not change the response to meal. Symptom score improved significantly after cisapride and placebo. It is concluded that in dyspeptic patients with reduced gallbladder response to a meal, cisapride may be of help in improving the kinetic abnormality. Dyspeptic symptoms, however, do not seem to be corrected with the described gallbladder motor abnormality.

Key Words

gallbladder motility ultrasonography dyspepsia 

Copyright information

© Plenum Publishing Corporation 1992

Authors and Affiliations

  • Leonardo Marzio
    • 1
  • Franca DiFelice
    • 1
  • Maria Grazia Laico
    • 1
  • Bruno Imbimbo
    • 1
  • Domenico Lapenna
    • 1
  • Franco Cuccurullo
    • 1
  1. 1.Institute of Medical PhysiopathologyG. D.'Annunzio UniversityChietiItaly
  2. 2.Patologia MedicaOspedale Civile SS.AnnunziataChietiItaly

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