Summary
Previous reports have indicated that administration of flutamide—a nonsteroidal antiandrogen drug—may induce hepatic toxicity. However, cholestatic hepatitis following flutamide is a rare event. This case report describes a 72-year-old male with metastatic adenocarcinoma of the prostate who underwent bilateral orchiectomy and treatment with flutamide. After seven weeks he developed jaundice and elevated AST and ALT levels. A liver biopsy showed cholestatic hepatitis without signs of biliary obstruction. The patient's clinical symptoms and elevated bilirubin resolved after the flutamide was discontinued. Monitoring of serum liver enzyme tests is advocated during flutamide administration to identify drug-induced liver injury.
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Rosman, A.S., Frissora-Rodeo, C., Marshall, A.T. et al. Cholestatic hepatitis following flutamide. Digest Dis Sci 38, 1756–1759 (1993). https://doi.org/10.1007/BF01303188
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DOI: https://doi.org/10.1007/BF01303188