Digestive Diseases and Sciences

, Volume 38, Issue 9, pp 1619–1623

Nonsteroidal antiinflammatory drugs and lower gastrointestinal bleeding

  • Stephen Holt
  • Vincent Rigoglioso
  • Malwinder Sidhu
  • Mohamed Irshad
  • Colin W. Howden
  • Michael Mainero
Original Articles

DOI: 10.1007/BF01303169

Cite this article as:
Holt, S., Rigoglioso, V., Sidhu, M. et al. Digest Dis Sci (1993) 38: 1619. doi:10.1007/BF01303169

Abstract

To define the association of the ingestion of nonsteroidal anti-inflammatory drugs (NSAIDs), including aspirin (ASA), and lower gastrointestinal bleeding (GIB) a retrospective, case-controlled study was undertaken of 188 patients admitted to three community hospitals in three cities with a diagnosis of lower GIB. Information was obtained about NSAID usage among these patients, and the data were compared with an age- and sex-matched control group of 185 patients admitted with a nongastrointestinal diagnosis, derived from a daily admission list. At the time of admission, in the New Jersey group, NSAID consumption was present in 26 of 90 (29%) patients with lower GIB compared with 16 of 90 (18%) of controls (P<0.05, odds ratio 1.88, 95% CI 1.2–3.1) whereas, in the South Carolina group 34 of 98 (35%) were taking NSAID compared with 18 of 95 (19%) of controls (P<0.01, odds ratio 2.27, 95% CI 1.2–4.4). These data indicate that there is a significantly increased rate of NSAID ingestion in patients admitted with lower GIB, implying that NSAID may unmask bleeding from a variety of lower gastrointestinal lesions.

Key Words

nonsteroidal antiinflammatory drugsaspiringastrointestinal bleeding

Copyright information

© Plenum Publishing Corporation 1993

Authors and Affiliations

  • Stephen Holt
    • 1
    • 2
    • 3
    • 4
  • Vincent Rigoglioso
    • 1
    • 2
    • 3
    • 4
  • Malwinder Sidhu
    • 1
    • 2
    • 3
    • 4
  • Mohamed Irshad
    • 1
    • 2
    • 3
    • 4
  • Colin W. Howden
    • 1
    • 2
    • 3
    • 4
  • Michael Mainero
    • 1
    • 2
    • 3
    • 4
  1. 1.Saint Michael's Medical CenterSeton Hall UniversityNewark
  2. 2.Saint Michael's Medical CenterNew Jersey Institute of TechnologyNewark
  3. 3.Joseph's Medical CenterPaterson
  4. 4.School of MedicineUniversity of South CarolinaColumbia