World Journal of Urology

, Volume 15, Issue 6, pp 331–335

Population-based prostate cancer trends in the United States: patterns of change in the era of prostate-specific antigen


DOI: 10.1007/BF01300179

Cite this article as:
Stephenson, R.A. & Stanford, J.L. World J Urol (1997) 15: 331. doi:10.1007/BF01300179


We reviewed prostate cancer trends prior to and during the prostate-specific antigen (PSA) era using data reported from population-based tumor registries in the United States. On the basis of a summary of reports from several population-based tumor registries, prostate cancer incidence rose abruptly during the PSA era, peaked in 1992, and then fell just as abruptly. Prostate cancer incidence in the United States now appears to be approaching levels seen in the pre-PSA era. The flux in prostate cancer incidence (in both magnitude and slope) during the years 1988–1995 is without precedent in oncology. As expected, an age and stage migration toward early age and early stage has been observed. Unexpectedly, grade has shifted heavily toward moderate differentiation, whereas rates of poorly and well-differentiated disease have remained relatively stable. Local treatment rates, particularly radical prostatectomy rates, have risen substantially. Mortality rates appear to have leveled or declined slightly since 1991 after years of steady rise.

Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  1. 1.Department of SurgeryUniversity of Utah School of MedicineSalt Lake CityUtahUSA
  2. 2.Department of Oncological SciencesUniversity of Utah School of MedicineSalt Lake CityUSA
  3. 3.Division of Urology, Room 3B 420University of Utah School of MedicineSalt Lake CityUSA