Digestive Diseases and Sciences

, Volume 36, Issue 1, pp 47–51

Effect of synthetic prostaglandin E1 analog (ornoprostil) on gastric emptying and pancreatic polypeptide release after solid-meal ingestion in man

  • Hiroyuki Okano
  • Susumu Saeki
  • Akio Inui
  • Yukio Kawai
  • Shinsuke Morimoto
  • Akiyoshi Ohmoto
  • Takatoshi Nakashima
  • Masaki Miyamoto
  • Toumei Oh
  • Akihiko Takata
  • Hideki Mitooka
  • Yoshinobu Tomofuji
  • Tsutomu Yasuda
  • Shigeaki Baba
  • Masato Kasuga
Original Articles

DOI: 10.1007/BF01300086

Cite this article as:
Okano, H., Saeki, S., Inui, A. et al. Digest Dis Sci (1991) 36: 47. doi:10.1007/BF01300086

Abstract

The effect of orally administered ornoprostil, 17S,20-dimethyl-6-oxoprostaglandin E1 methyl ester, on gastric emptying and on pancreatic polypeptide (PP) release after solid meal ingestion, was investigated in man. A radionuclide technique was used to measure gastric emptying of eight healthy volunteers. In addition, four parameters [SI (starting index): the lag time in the start of emptying;K value: the emptying rate;T1/2: the half emptying time; 120 min RR: the percent retention at 120 min] were determined for evaluation. Also, the PP response was analyzed according to two parameters: IPPRSI, the integrated PP response for periods up to SI, and IPPR120, the integrated PP response for 120 min. The results demonstrated that 5 μg of orally administered ornoprostil significantly reduced the gastric emptying rate of solid meal (T1/2 and 120 min RR,P<0.05). However, ornoprostil affected neither the basal PP concentrations nor the cephalic phase of PP secretion which was determined as IPPRSI. This thus suggests that ornoprostil affects the gastric motor function without interfering with the vagal-cholinergic pathway to the stomach.

Key Words

prostaglandin E1gastric emptyingsolid mealpancreatic polypeptide

Copyright information

© Plenum Publishing Corporation 1991

Authors and Affiliations

  • Hiroyuki Okano
    • 1
    • 2
  • Susumu Saeki
    • 1
    • 2
  • Akio Inui
    • 1
    • 2
  • Yukio Kawai
    • 1
    • 2
  • Shinsuke Morimoto
    • 1
    • 2
  • Akiyoshi Ohmoto
    • 1
    • 2
  • Takatoshi Nakashima
    • 1
    • 2
  • Masaki Miyamoto
    • 1
    • 2
  • Toumei Oh
    • 1
    • 2
  • Akihiko Takata
    • 1
    • 2
  • Hideki Mitooka
    • 1
    • 2
  • Yoshinobu Tomofuji
    • 1
    • 2
  • Tsutomu Yasuda
    • 1
    • 2
  • Shigeaki Baba
    • 1
    • 2
  • Masato Kasuga
    • 1
    • 2
  1. 1.Second Department of Internal MedicineKobe University School of MedicineKobeJapan
  2. 2.Hyogo Institute for Research in Adult DiseasesAkashiJapan