Original Articles

Digestive Diseases and Sciences

, Volume 36, Issue 8, pp 1084-1088

First online:

Seroepidemiology ofHelicobacter pylori infection in India

Comparison of developing and developed countries
  • David Y. GrahamAffiliated withDepartment of Medicine and Division of Molecular Virology, Veterans Affairs Medical Center and Baylor College of MedicineDeccan Pathological Institute, Osmania General HospitalNiloufer Hospital
  • , Ervin AdamAffiliated withDepartment of Medicine and Division of Molecular Virology, Veterans Affairs Medical Center and Baylor College of MedicineDeccan Pathological Institute, Osmania General HospitalNiloufer Hospital
  • , Gurunath T. ReddyAffiliated withDepartment of Medicine and Division of Molecular Virology, Veterans Affairs Medical Center and Baylor College of MedicineDeccan Pathological Institute, Osmania General HospitalNiloufer Hospital
  • , Jai Prakash AgarwalAffiliated withDepartment of Medicine and Division of Molecular Virology, Veterans Affairs Medical Center and Baylor College of MedicineDeccan Pathological Institute, Osmania General HospitalNiloufer Hospital
  • , Rohit AgarwalAffiliated withDepartment of Medicine and Division of Molecular Virology, Veterans Affairs Medical Center and Baylor College of MedicineDeccan Pathological Institute, Osmania General HospitalNiloufer Hospital
  • , Doyle J. EvansJr.Affiliated withDepartment of Medicine and Division of Molecular Virology, Veterans Affairs Medical Center and Baylor College of MedicineDeccan Pathological Institute, Osmania General HospitalNiloufer Hospital
  • , Hoda M. MalatyAffiliated withDepartment of Medicine and Division of Molecular Virology, Veterans Affairs Medical Center and Baylor College of MedicineDeccan Pathological Institute, Osmania General HospitalNiloufer Hospital
  • , Dolores G. EvansAffiliated withDepartment of Medicine and Division of Molecular Virology, Veterans Affairs Medical Center and Baylor College of MedicineDeccan Pathological Institute, Osmania General HospitalNiloufer Hospital

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

Helicobacter pylori (previouslyCampylobacter pylori) is now accepted as the major cause of type B gastritis and thus what is known about the epidemiology of type B gastritis can reasonably be transferred toH. pylori. We used a specific ELISA for anti-H. pylori IgG to study the prevalence ofH. pylori infection in a population of lower socioeconomic class from Hyderabad, India. The results from India were compared to studies from other parts of the world. Two hundred thirty-eight individuals ages 3 to 70 participated. The frequency ofH. pylori infection increased with age (P<0.01) and was >80% by age 20.H. pylori infection was present in 79% of the population studied; there was no gender-related difference in prevalence ofH. pylori infection. IgG antibody against hepatitis A (HAV) was rapidly acquired in Hyderabad; in a subset of 58 children between the ages of 3 and 21 tested, the frequency of anti-HAV was 98.2%. The prevalenc ofH. pylori infection increases with age in both developed and developing countries. The high age-specific prevalence ofH. pylori infection in developing countries is probably a reflection of the lower socioeconomic level of those areas.

Key Words

Helicobacter pylori seroepidemiology race age-specific socioeconomic group hepatitis A