Digestive Diseases and Sciences

, Volume 31, Issue 7, pp 700–704

HBsAg clearance in chronic active hepatitis B

A possible cause of cryptogenic cirrhosis
  • Timothy R. Morgan
  • Allan G. Redeker
  • Suyenori Yamada
  • Mary Ashcavai
Original Articles

DOI: 10.1007/BF01296446

Cite this article as:
Morgan, T.R., Redeker, A.G., Yamada, S. et al. Digest Dis Sci (1986) 31: 700. doi:10.1007/BF01296446

Abstract

Three patients with chronic hepatitis B infection, two with chronic active hepatitis and cirrhosis, and the third with quiescent cirrhosis, cleared HBsAg from their serum and eventually developed anti-HBs. All three were asymptomatic and had nearly normal serum aminotransferases following loss of HBsAg. Liver biopsy revealed cirrhosis in each patient. With the development of anti-HBs, these patients became serologically indistinguishable from patients with a cryptogenic cirrhosis who had prior unrelated exposure to hepatitis B. Remote chronic hepatitis B infection may be a more common cause of cryptogenic cirrhosis than is commonly appreciated.

Copyright information

© Plenum Publishing Corporation 1986

Authors and Affiliations

  • Timothy R. Morgan
    • 1
  • Allan G. Redeker
    • 1
  • Suyenori Yamada
    • 1
  • Mary Ashcavai
    • 1
  1. 1.Liver Unit, Departments of Medicine and PathologyUniversity of Southern California School of Medicine, Rancho Los Amigos HospitalDowney

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