Journal of Neural Transmission

, Volume 104, Issue 11, pp 1287–1293

Cerebrospinal fluid levels of alpha-tocopherol (vitamin E) in Parkinson's disease

  • J. A. Molina
  • F. de Bustos
  • F. J. Jiménez-Jiménez
  • J. Benito-León
  • M. Ortí-Pareja
  • T. Gasallo
  • A. Tallón-Barranco
  • J. A. Navarro
  • J. Arenas
  • R. Enríquez-de-Salamanca
Parkinson's Disease and Allied Conditions

DOI: 10.1007/BF01294729

Cite this article as:
Molina, J.A., de Bustos, F., Jiménez-Jiménez, F.J. et al. J. Neural Transmission (1997) 104: 1287. doi:10.1007/BF01294729

Summary

We compared CSF and serum levels, and the CSF/serum ratio of alpha-tocopherol (vitamin E), measured by HPLC, in 34 patients with Parkinson's disease (PD) and 47 controls. CSF and serum vitamin E levels were correlate. The mean CSF and serum vitamin E levels, and the CSF/serum ratio of PD patients did not differ significantly between the groups.

There was no influence of antiparkinsonian therapy on CSF vitamin E levels. CSF vitamin E levels did not correlate with age, age at onset, duration of the disease, scores of the Unified Parkinson Disease Rating Scale of the Hoehn and Yahr staging in the PD group. These results suggest that CSF vitamin E concentrations are unrelated with the risk for PD.

Keywords

Parkinson's disease alpha-tocopherol vitamin E cerebrospinal fluid levels serum levels 

Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • J. A. Molina
    • 1
  • F. de Bustos
    • 2
  • F. J. Jiménez-Jiménez
    • 3
  • J. Benito-León
    • 1
  • M. Ortí-Pareja
    • 3
  • T. Gasallo
    • 3
  • A. Tallón-Barranco
    • 3
  • J. A. Navarro
    • 2
  • J. Arenas
    • 2
  • R. Enríquez-de-Salamanca
    • 4
  1. 1.Department of NeurologyHospital Universitario Doce de OctubreSpain
  2. 2.Department of BiochemistryHospital Universitario Doce de OctubreSpain
  3. 3.Department of NeurologyHospital Universitario “Principe de Asturias”Alcalá de Henares
  4. 4.Department of MedicineUniversidad ComplutenseMadridSpain
  5. 5.MadridSpain