Journal of Neural Transmission

, Volume 103, Issue 1, pp 101–115

Brain monoaminergic and neuropeptidergic variations in human aging

  • B. Arranz
  • K. Blennow
  • R. Ekman
  • A. Eriksson
  • J. -E. Månsson
  • J. Marcusson
Parkinson's Disease and Allied Conditions

DOI: 10.1007/BF01292620

Cite this article as:
Arranz, B., Blennow, K., Ekman, R. et al. J. Neural Transmission (1996) 103: 101. doi:10.1007/BF01292620

Summary

The effect of age on the monoamines 5-hydroxytryptamine (5-HT), noradrenaline (NA) and dopamine (DA), their metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), 3,4-dihydr-oxyphenylacetic acid (DOPAC), and the 5-HT precursor 5-hydroxy-L-tryptophan (5-HTP), together with the peptides neuropeptide Y (NPY), somatostatin (SOM), and corticotropin-releasing factor (CRF), was studied in frontal cortex, gyrus cinguli and hypothalamus from 23 healthy control subjects, aged 16–75 years. After correcting for postmortem interval, significant decreases in gyrus cinguli NA, NPY and CRF, and hypothalamic DA, HVA, and 5-HIAA concentrations were obtained with advancing age. The involvement of the monoaminergic system in several functional abnormalities appearing in senescence is suggested. Furthermore, evidence is given of the participation of the peptidergic systems in the aging process.

Keywords

Human brainagingmonoaminesneuropeptide Ysomatostatincorticotropin-releasing factorHPLC

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • B. Arranz
    • 1
    • 2
  • K. Blennow
    • 3
  • R. Ekman
    • 3
  • A. Eriksson
    • 4
  • J. -E. Månsson
    • 3
  • J. Marcusson
    • 1
  1. 1.Department of Geriatric MedicineUniversity of LinköpingSweden
  2. 2.Departments of Pharmacology and PsychiatryInstitut Municipal d'Investigació MèdicaBarcelonaSpain
  3. 3.Department of Clinical Neuroscience, Section of NeurochemistryUniversity of Göteborg, Mölndal HospitalSweden
  4. 4.Department of Forensic MedicineUniversity of UmeåSweden