Journal of Neural Transmission

, Volume 104, Issue 8, pp 931–941

Homozygous thermolabile methylenetetrahydrofolate reductase in schizophrenia-like psychosis

  • B. Regland
  • T. Germgård
  • C. G. Gottfries
  • B. Grenfeldt
  • A. C. Koch-Schmidt
Biological Psychiatry

DOI: 10.1007/BF01285561

Cite this article as:
Regland, B., Germgård, T., Gottfries, C.G. et al. J. Neural Transmission (1997) 104: 931. doi:10.1007/BF01285561

Summary

The gene for methylenetetrahydrofolate reductase (MTHFR) has shown polymorphism in the general human population. In its homozygous form, a C677T mutation occurs in more than 5% of the grown-up population and produces a thermolabile variant which reduces the overall enzyme activity to less than 30% of normal. We investigated patients with schizophrenia-like psychosis. If hyperhomocysteinemic, their DNA-genotype for thermolabile C677T mutation was determined. Seven of 11 patients, six males and one female, were homozygous for thermolabile MTHFR. One male patient was heterozygous and all three normal homozygotes were females. In the patients who were homozygous for the C677T mutation, the homocysteine concentrations did not respond to vitamin B12 but were normalized by folate supplementation. In the normal homozygotes, however, the homocysteine concentrations were reduced by vitamin B12 alone. Our results suggest that homozygosity for thermolabile MTHFR is a risk factor for schizophrenia-like psychosis. Possibly, this risk may be reduced by folate supplementation.

Keywords

Schizophreniahyperhomocysteinemiathermolabile methylenetetrahydrofolate reductase

Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • B. Regland
    • 1
  • T. Germgård
    • 2
  • C. G. Gottfries
    • 1
  • B. Grenfeldt
    • 1
  • A. C. Koch-Schmidt
    • 2
  1. 1.Institute of Clinical NeuroscienceGöteborg UniversitySweden
  2. 2.Department of Natural SciencesKalmar UniversitySweden
  3. 3.Department of PsychiatryMölndal Hospital80 MölndalSweden