Journal of Neural Transmission

, Volume 103, Issue 4, pp 503–507

Increased density of entorhinal glutamate-immunoreactive vertical fibers in schizophrenia

Authors

  • D. Longson
    • Laboratory for Structural NeuroscienceMcLean Hospital
  • J. F. W. Deakin
    • School of Psychiatry and Behavioural SciencesUniversity of Manchester
  • F. M. Benes
    • Department of PsychiatryHarvard Medical School
Short Communication Biological Psychiatry

DOI: 10.1007/BF01276423

Cite this article as:
Longson, D., Deakin, J.F.W. & Benes, F.M. J. Neural Transmission (1996) 103: 503. doi:10.1007/BF01276423

Summary

Gluatamtergic fibers have been immunocytochemically localized in the entorhinal cortex of postmortem schizophrenic brains. The density of small caliber vertical fibers was higher in schizophrenics than controls, with no significant increase in the number of large caliber fibers. Increased glutamatergic fiber density has been previously reported in the cingulate cortex. It is proposed that increases in glutamatergic fibers from the amygdala may be responsible for these changes and that they may play a central role in the pathophysiology of schizophrenia.

Keywords

Schizophreniaentorhinalglutamate

Copyright information

© Springer-Verlag 1996