Journal of Neural Transmission / General Section JNT

, Volume 99, Issue 1, pp 145–155

Neuroimaging in alcoholism: CT and MRI results and clinical correlates


  • K. Mann
    • Department of PsychiatryUniversity of Tübingen Medical School
  • G. Mundle
    • Department of PsychiatryUniversity of Tübingen Medical School
  • M. Strayle
    • Department of RadiologyUniversity of Tübingen Medical School
  • P. Wakat
    • Department of NeuroradiologyUniversity of Tübingen Medical School
Full Papers

DOI: 10.1007/BF01271475

Cite this article as:
Mann, K., Mundle, G., Strayle, M. et al. J. Neural Transmission (1995) 99: 145. doi:10.1007/BF01271475


For more than a century we have known the deleterious effects of alcohol on the brain regions surrounding the third ventricle and on the cerebellum. But it was only recently that we gained clearer evidence that the cortex is affected as well. Our imaging studies show that brain shrinkage is at least partially reversible once abstinence is maintained. They confirm results obtained in different laboratories from all over the world. Although our data contradict the rehydration hypothesis and thus lend credence to the idea of regeneration and neuroplasticity, the nature of reversibility is still a matter of debate.


Alcoholismbrain damageneuroplasticityneuropathologyMRICT

Copyright information

© Springer-Verlag 1995