Journal of Neural Transmission

, Volume 33, Issue 2, pp 163–178

The balance of biogenic amines as condition for normal behaviour

  • W. Birkmayer
  • W. Danielczyk
  • E. Neumayer
  • P. Riederer
Article

DOI: 10.1007/BF01260902

Cite this article as:
Birkmayer, W., Danielczyk, W., Neumayer, E. et al. J. Neural Transmission (1972) 33: 163. doi:10.1007/BF01260902

Summary

An accumulation of norepinephrin, serotonin and dopamin exists in the brainstem. A decrease of biogenic amines in the brains of Parkinson's cases has been demonstrated. A substitution by the precursor L-DOPA produces an increase of dopamin in the brain and a decrease of serotonin. The high level of dopamin improves the akinesia and the depletion of serotonin causes a toxic delir. A substitution by l-tryptophan restores the balance and the Dopa-psychosis disappears.

Copyright information

© Springer-Verlag 1972

Authors and Affiliations

  • W. Birkmayer
    • 1
  • W. Danielczyk
    • 1
  • E. Neumayer
    • 1
  • P. Riederer
    • 1
  1. 1.Ludwig-Boltzmann-Institut für Neurochemie und neurologische Abteilung des Alterskrankenhauses der Stadt Wien-LainzÖsterreich