Journal of Neural Transmission

, Volume 71, Issue 1, pp 73–78

Effect of adjuvant reserpine treatment on catecholamine metabolism in schizophrenic patients under long-term neuroleptic treatment

  • G. Bagdy
  • G. Perenyi
  • E. Frecska
  • A. Seregi
  • M. I. K. Fekete
  • L. Tothfalusi
  • K. Magyar
  • A. Bela
  • M. Arato
Original Papers

DOI: 10.1007/BF01259412

Cite this article as:
Bagdy, G., Perenyi, G., Frecska, E. et al. J. Neural Transmission (1988) 71: 73. doi:10.1007/BF01259412

Summary

The clinical and biochemical effects of adjuvant reserpine treatment were investigated in 12 chronic schizophrenic patients on long-term neuroleptic medication. The global severity of the symptoms using the Brief Psychiatric Rating Scale did not change significantly in the whole group, however, a moderate decrease in positive symptoms (factors though disturbance, activation and hostile-suspiciousness) was observed for 5 patients. Cerebrospinal fluid (CSF) noradrenaline levels showed a consistent decrease, but other biochemical parameters (CSF dopamine metabolites, platelet MAO and serum dopamine-β-hydroxylase activities) did not change significantly. The changes of clinical symptoms and biochemical parameters did not show any correlation.

Keywords

Schizophrenia neuroleptics reserpine cerebrospinal fluid amines metabolites c-AMP serum prolactin enzymes 

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • G. Bagdy
    • 1
  • G. Perenyi
    • 1
  • E. Frecska
    • 1
  • A. Seregi
    • 2
  • M. I. K. Fekete
    • 2
  • L. Tothfalusi
    • 3
  • K. Magyar
    • 3
  • A. Bela
    • 4
  • M. Arato
    • 1
  1. 1.National Institute for Nervous and Mental DiseasesBudapestHungary
  2. 2.Institute of Experimental MedicineHungarian Academy of SciencesBudapestHungary
  3. 3.Department of PharmacodynamicsSemmelweis University of MedicineBudapestHungary
  4. 4.Department of PsychiatryGyongyos HospitalGyongyosHungary
  5. 5.Laboratory of Clinical Science, National Institute of Mental HealthNational Institutes of HealthBethesdaUSA

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