Summary
The highly significant increase of 5-HIAA (5-hydroxyindole-3-acetic acid) in Transcendental Meditation technique suggests systemic serotonin as “rest and fulfillment hormone” of deactivation-relaxation.
Furthermore 5-HT (5-hydroxytryptamine, serotonin) is considered to to be the EC-cell (enterochromaffine-cell) hormone requested byFujita andKobayashi and its role for EEG synchronisation via area postrema chemo-receptor as anti arousal agent is being discussed.
The significant decrease of the catecholamine metabolite VMA (vanillic-mandelic acid) in meditators, that is associated with a reciprocal increase of 5-HIAA supports as a feedback necessity the “rest and fulfillment response” versus “fight and flight”.
As the adreno medullary tissue serves for hormonal reinforcement of orthosympathetic activity, the Enterochromaffine Cell System (having taken the form of distinct organs in some species as octopus and discoglossus) is suggested to serve via serotonin for humoral reinforcement of parasympathetic activity in deep relaxation.
References
Banquet, J.-P.: EEG and Meditation. Electroencephalography and Clinical Neurophysiology33, 454 (1972).
Banquet, J.-P.: Spectral Analysis of the EEG in Meditation. Electroence-phalography and Clinical Neurophysiology35, 143–151 (1973).
Benson, H., Wallace, R. K.: Decreased Drug Abuse with Transcendental Meditation: A study of 1862 Subjects. Drug Abuse: Proceedings of the International Conference (Zarafonetis, Chris J. D., ed.), pp. 369–376. Philadelphia: Lea and Febiger. 1972, and Congressional Record, Serial No. 92-1 (Washington D.C., U.S.A.: Government Printing Office, 1971).
Birkmayer, W., Pilleri, G.: Die retikuläre Formation des Hirnstammes und ihre Bedeutung für das vegetativ-affektive Verhalten. Hoffmann- La Roche & Co. AG., Basel (1965). Wissenschaftl. Dienst.
Birkmayer, W., Danielczyk, W., Riederer, P.: Biogene Transmitter und Akupunktur. In: Handbuch für Akupunktur (Bischko, J., ed.), pp. 3 to 21. Haug Verlag. 1976.
Bujatti, M.: Design for a Systemtheory of Man. MERU-Journal, in press (1976).
Busolati, G., Pearse, A. G. E.: Immunofluorescent localization of the gastrin-secreting G cells in the pyloric antrum of the pig. Histochemie21, 1–4 (1970).
Bülbring, E., Lin, R. C. Y.: J. Physiol. (London)140, 381–407 (1958).
Bülbring, E., Crema, A.: J. Physiol. (London)146, 18–28, 29–53 (1959).
Ciacco, T.: Sur une nouvelle espèce cellulaire dans les glandes de Lieberkühn. Compt. Rend. Soc. Biol. (Paris)60, 76 (1906).
Erspamer, V., Acero, B.: Identification of enteramine, the specific hormone of the enterochromaffin cell system as 5-hydroxytryptamine. Nature (London)169, 800–801 (1952).
Erspamer, V.: Comparative Endocrinology. U. S. von Euler, Academic Press (1963), Vol. 2.
Euler, U. S. von: Chromaffin Cell Hormones. In: Comparative Endo-crinology (Euler, U. S. von, Heller, H., eds.), Vol. l, pp. 258–290. New York: Academic Press. 1963.
Feyrter, F.: Über die peripheren endokrinen (parakinen) Drüsen des Menschen. Verlag für medizinische Wissenschaften, Wilhelm Maudrich, Wien-Düsseldorf (1953).
Feyrter, F.: Über diffuse endokrine epitheliale Organe, pp. 2 to 9. Leipzig: J. A. Barth. 1938.
Frankenhaeuser, M.: Biochemische Indikatoren der Aktiviertheit: Die Ausscheidung von Katecholaminen. In: Methoden der Aktivierungsforschung (Schönpflug, W., ed.). Bern: Hans Huber. 1969.
Fujita, T., Kobayashi, S.: Gastro-Entero-Pancreatic Endocrine System. The Cells and Hormones of the GEP Endocrine System, pp. 1–16. Stuttgart: Georg Thieme Publishers. 1974.
Gaillard, J. M., Bartholini, G., Herkert, B., Tissot, R.: Involvement of 5-hydroxytryptamine in the cortical synchronisation induced by L-Dopa in the rabbit. Brain Research68, 344–350 (1974).
Hamon, M., Glowinsky, J.: Regulation of Serotonin Synthesis. Life Sciences15, 1533–1548 (1974).
Hunsky, J., Korman, M. G., Gowiey, D. J., Baron, J. H.: Serum gastrin in duodenal ulcer: 11. Effect of insulin hypoglycaemia. Gut.12, 959–962 (1971).
Jevning, R., Wilson, A., Vanderlaan, E., Levine, S.: Plasma Prolactin and Cortisol during Transcendental Meditation, Proceedings of the Endocrine Society, in press (1975). Reprinted in Scientific Research on the TM-Program: Collected Papers, Vol. 1 (MERU Press Publication Number S 180).
Johnson, L. P., Jesseph, J. E.: Evidence for a humoral etiology of the dumping syndrome. Surg. Forum12, 316 (1961).
Johnson, L. P., Sloop, R. D., Jesseph, J. E., Harling, H. N.: Serotonin antagonists in experimental and clinical “dumping”. Anm. Surg.156, 537–545 (1962).
Karoum, F., Anah, C. O., Ruthven, C. R. J., Sandler, M.: Further Observation on the Gaschromatographic Measurement of Uurinary phenolic and indolic metabolites. Clin. Chim. Acta24, 341–348 (1969).
Kobal, G., Wandhöfer, A., Plattig, K. H.: EEC power spectra and auditory evoked potentials in transcendental meditation. 45. Deutsche Physiologentagung in Wien, 1975.
Koella, W. P., Czicman, J. S.: The area postrema as a possible receptor site for EEG synchronisation by 5-HT. Federation Proceedings24, 646 (1965).
Koella, W. P.: Serotonin—A Hypogenic Transmitter and an Antiwaking Agent. Advances in Biochemical Psychoparmacology, Vol. 11. New York: Raven Press. 1974.
Koella, W. P., Czicman, J. S.: Mechanism of the EEC-synchronizing action of serotonin. American Journal of Physiology211, 926–934 (1966).
Krahne, W.: EEG und Transzendentale Meditation. 45. Deutsche Physiologentagung in Wien, 1975. Deutsche Physiologische Gesellschaft.
Kursky, M. D.: Ukrainskii Biokhimichnii Zhurnal6, Vol. 46 (1974).
Lee, C. Y.: J. Physiol. (London)152, 405–418 (1960).
Maharishi, M. Y.: The science of being and the art of living, p. 335. London: Int. SRM Publ. 1966.
Matsuo, Y., Seki, A., Kitamura, A.: Gastro-Entero-Pancreatic Endocrine System. Splanchnic Nerve and Gastrin, pp. 128–134. Stuttgart: Georg Thieme Publishers. 1974.
Menguy, R.: Gastric mucus and the gastric mucous barrier. Amer. J. Surg.117, 806–812 (1969).
Mitschke, H.: Vergleichende immunohistologische und cytochemische Untersuchungen der Gastrinzellen beim Menschen. Virchows Arch. Abt. Pathol. Anat.353, 347–359 (1971).
Oates, J. A., Pettinger, W. A., Doctor, R. B.: Evidence for the release of bradykinin in cardinoid syndrome. J. clin. Invest.45, 173–178 (1966).
Orme-Jobnson, D., Farrow, J.: Scientific Research on the Transcendental Meditation Program. Collected Papers, Vol. 1, p. 702. New York: MIU Press. 1976.
Osaka, M., Sasagawa, T., Fujita, T.: Gastro-Entero-Pancreatic Endocrine System. Emiocytotic granule reseale in the human antralendocrine cell, pp. 59–64. Stuttgart: Georg Thieme Publishers. 1974.
Pe Thein, Shofield, B.: Release of gastrin the pyloric antrum following vagal stimulation by sham feeding in dogs. J. Physiol.148, 291–305 (1959).
Porter, C. C., Totaro, J. A., Leiby, C. M.: J. Pharmacol. Exptl. Therap.134, 139–145 (1961).
Riederer, P., Birkmayer, W., Neumayer, E., Ambrozi, L., Linauer, W.: The Daily Rhythm of HVA, VMA, (VA) and 5-HIAA in Depression-syndrom. Journal of Neural Transmission35, 23–45 (1974).
Riederer, P., Tenk, H., Werner, H., Bischko, J., Rett, A., Krisper, H.: Manipulation of Neurotransmitters by Acupuncture(?). Journal of Neural Transmission37, 81–94 (1975).
Sandler, M., Ruthven, C. R. J., Fellow, L.: Personal Communication (1973).
Shafii, M., Lavely, R. A., Jaffe, R. D.: Meditation and Marijuana. American Journal of Psychiatry131, no. 1, 60–63 (1974).
Selye, H.: TM discovering inner energy and overcoming stress (Bloomfield, H. H.). New York: Delacorte Press. 1975.
Sleisenger, W. H., Law, D. H., Smith, F. W., Pert, J. H., Lewis, Ch. M.: J. Clin. Invest.38, 2119–2130 (1959).
Solcia, E., Sampietro, R.: Cytologie observations on the pancreatic islets with reference to some endocrine-like cells of the gastrointestinal mucosa. Z. Zellforsch.68, 689–698 (1965).
Tobe, T., Kimura, C., Fujiwara, M.: Role of 5-hydroxytryptamine in the dumping syndrome after gastroectomy. Histochemical study. Anm. Surg.165, 382–387 (1967).
Thorson, A. H.: Acta Med. Scand.161, Suppl. 334, 1–132 (1942).
Uvnas, B.: The part played by the pyloric region in the cephalic phase of gastric secretion. Acta physiol. Scand.13, Supp. 4, 1–86 (1942).
Wallace, R. K., Benson, H., Wilson, A. F.: A Wakeful Hypometabolic Physiologic State. American Journal of Physiology221, no. 3, 795–799 (1971).
Author information
Authors and Affiliations
Additional information
The results of this work have been partly contributed to the neuroscience meeting Sept. 4, 1975 at Courchevel and the MERU-Symposium Hamburg May 22, 1976.
Rights and permissions
About this article
Cite this article
Bujatti, M., Biederer, P. Serotonin, noradrenaline, dopamine metabolites in transcendental meditation-technique. J. Neural Transmission 39, 257–267 (1976). https://doi.org/10.1007/BF01256514
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01256514