Journal of Neural Transmission

, Volume 65, Issue 2, pp 147–150

Equol and other compounds from bovine urine as monoamine oxidase inhibitors

Authors

  • Deborah Dewar
    • Bernhard Baron Memorial Research Laboratories and Institute of Obstetrics and GynaecologyQueen Charlotte's Maternity Hospital
  • Vivette Glover
    • Bernhard Baron Memorial Research Laboratories and Institute of Obstetrics and GynaecologyQueen Charlotte's Maternity Hospital
  • J. Elsworth
    • Bernhard Baron Memorial Research Laboratories and Institute of Obstetrics and GynaecologyQueen Charlotte's Maternity Hospital
  • M. Sandler
    • Bernhard Baron Memorial Research Laboratories and Institute of Obstetrics and GynaecologyQueen Charlotte's Maternity Hospital
Short Notes

DOI: 10.1007/BF01256490

Cite this article as:
Dewar, D., Glover, V., Elsworth, J. et al. J. Neural Transmission (1986) 65: 147. doi:10.1007/BF01256490

Summary

Equol, its methylated derivative, and a carbazole, all isolated from bovine urine, are relatively potent inhibitors of monoamine oxidase with IC50 values of 158, 28, and 16μM respectively (using 83μM tyramine as substrate). The probable dietary origin of these compounds suggests that “natural” monoamine oxidase inhibitors may be more widespread than had previously been suspected.

Key words

Equolmonoamine oxidase inhibitionbenzodiazepine receptor binding inhibitionbovine urinedietary isoflavans

Copyright information

© Springer-Verlag 1986