Equol and other compounds from bovine urine as monoamine oxidase inhibitors Authors
Received: 23 January 1985 Revised: 11 October 1985 DOI:
Cite this article as: Dewar, D., Glover, V., Elsworth, J. et al. J. Neural Transmission (1986) 65: 147. doi:10.1007/BF01256490 Summary
Equol, its methylated derivative, and a carbazole, all isolated from bovine urine, are relatively potent inhibitors of monoamine oxidase with IC
50 values of 158, 28, and 16 μM respectively (using 83 μM tyramine as substrate). The probable dietary origin of these compounds suggests that “natural” monoamine oxidase inhibitors may be more widespread than had previously been suspected. Key words Equol monoamine oxidase inhibition benzodiazepine receptor binding inhibition bovine urine dietary isoflavans References
Axelson, M., Sjövall, J., Gustafsson, B. E., Setchell, K. D. R.
: Soya — a dietary source of the non-steroidal oestrogen equol in man and animals. J. Endocr.
, 49–56 (1984).
Clow, A., Glover, V., Armando, I., Sandler, M.: New endogenous benzodiazepine receptor ligand in human urine: identity with endogenous monoamine oxidase inhibitor? Life Sci. 33, 735–741 (1983).
Glover, V., Liebowitz, J., Armando, I., Sandler, M.
-carbolines as selective monoamine oxidase inhibitors:
implications. J. Neural Transm.
, 209–218 (1982).
Luk, K.-C., Stern, L., Weigele, M., O'Brien, R. A., Spirt, N.: Isolation and identification of “diazepam-like” compounds from bovine urine. J. Natural Products 46, 852–861 (1983).
Shutt, D. A.
: The effects of plant oestrogens on animal reproduction. Endeavour
, 110–113 (1976).
Shutt, D. A., Braden, A. W. H.: The significance of equol in relation to the oestrogenic responses in sheep ingesting clover with a high formononetin content. Austral. J. Agric. Res. 19, 545–553 (1968).
Suzuki, O., Katsumata, Y., Oya, M., Chari, V. M., Vermes, B., Wagner, H., Hostettmann, K.
: Inhibition of type A and type B monoamine oxidases by naturally occurring xanthones. Planta Med.
, 17–21 (1981).
Truitt, E. B. jr., Duritz, G., Ebersberger, M.
: Evidence of monoamine oxidase inhibition by myristicin and nutmeg. Proc. Soc. Exp. Biol. Med.
, 647–650 (1963).