Equol and other compounds from bovine urine as monoamine oxidase inhibitors
Received: 23 January 1985 Revised: 11 October 1985 DOI:
Cite this article as: Dewar, D., Glover, V., Elsworth, J. et al. J. Neural Transmission (1986) 65: 147. doi:10.1007/BF01256490 Summary
Equol, its methylated derivative, and a carbazole, all isolated from bovine urine, are relatively potent inhibitors of monoamine oxidase with IC
50 values of 158, 28, and 16 μM respectively (using 83 μM tyramine as substrate). The probable dietary origin of these compounds suggests that “natural” monoamine oxidase inhibitors may be more widespread than had previously been suspected. Key words Equol monoamine oxidase inhibition benzodiazepine receptor binding inhibition bovine urine dietary isoflavans References
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