European Journal of Nuclear Medicine

, Volume 23, Issue 11, pp 1473–1477

Age-related changes in the global skeletal uptake of technetium-99m methylene diphosphonate in healthy women

  • Vincenzo Carnevale
  • Vincenzo Frusciante
  • Alfredo Scillitani
  • Sergio Modoni
  • Mauro Pileri
  • Iacopo Chiodini
  • Franca Dicembrino
  • Elisabetta Romagnoli
  • Salvatore Minisola
Original Article

DOI: 10.1007/BF01254471

Cite this article as:
Carnevale, V., Frusciante, V., Scillitani, A. et al. Eur J Nucl Med (1996) 23: 1473. doi:10.1007/BF01254471

Abstract

A short-term evaluation of global skeletal uptake (GSU) of technetium-99m methylene diphosphonate (MDP) was performed in 40 healthy female subjects with a wide age range in order to investigate the clinical performance of the technique and to detect the age-related changes in bone turnover. The results obtained were compared with measurements of the main biochemical markers of skeletal metabolism. We found that GSU increases progressively with age, independently of concomitant changes in renal function; significant correlations with biochemical markers of bone formation were also found. Therefore, the method appears to provide useful information concerning the bone turnover rate, and is also applicable to elderly people owing to its simplicity.

Key words

Bone turnoverGlobal skeletal uptakeAging

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • Vincenzo Carnevale
    • 1
  • Vincenzo Frusciante
    • 1
  • Alfredo Scillitani
    • 1
  • Sergio Modoni
    • 1
  • Mauro Pileri
    • 1
  • Iacopo Chiodini
    • 1
  • Franca Dicembrino
    • 1
  • Elisabetta Romagnoli
    • 2
  • Salvatore Minisola
    • 2
  1. 1.Ospedale “Casa Sollievo della Sofferenza”I.R.C.C.S. di San Giovanni RotondoFoggiaItaly
  2. 2.Istituto di II Clinica MedicaUniversità degli Studi di Roma “La Sapienza”RomeItaly
  3. 3.II Clinica MedicaPoliclinico Umberto 1RomeItaly