Journal of Neural Transmission

, Volume 36, Issue 3, pp 303–326

The potentiation of the anti akinetic effect after L-Dopa treatment by an inhibitor of Mao-B, deprenil

  • W. Birkmayer
  • P. Riederer
  • M. B. H. Youdim
  • W. Linauer
Article

DOI: 10.1007/BF01253131

Cite this article as:
Birkmayer, W., Riederer, P., Youdim, M.B.H. et al. J. Neural Transmission (1975) 36: 303. doi:10.1007/BF01253131

Summary

The potentiation of the ami akinetic effect after L-Dopa treatment by an inhibitor of monoamine oxidase (MAO) “B”, Deprenil, has been demonstrated in parkinsonian patients with or without previous L-Dopa therapy. Application of the drug has been performed orally, intravenously and intramuscularly. Excellent kinetic effects resulted when combined with Madopar. The combined treatment with L-Dopa was highly effective when applicated i.v. or i.m.

Deprenil is an inhibitor of MAO-B and is characterized by less frequent side effects. These are predominantly involuntary movements and confusion, which can be eliminated by lowering the dosage of Deprenil.

A daily rhythm of MAO could be demonstrated in several areas of human brains as well in a control group as in parkinsonian patients with or without L-Dopa therapy. Maximal activity of MAO occurs between noon and 6 p.m.

The clinical and biochemical data are discussed regarding the off-phenomenons as Deprenil is an excellent drug for preventing these.

Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • W. Birkmayer
    • 1
  • P. Riederer
    • 1
  • M. B. H. Youdim
    • 1
  • W. Linauer
    • 1
  1. 1.Ludwig-Boltzmann-Institut für NeurochemieGeriatrisches Krankenhaus der Stadt Wien-LainzAustria
  2. 2.MRC Clinical Pharmacology UnitRadcliffe InfirmaryOxfordGreat Britain
  3. 3.Evangelisches KrankenhausWien