Article

Journal of Neural Transmission / General Section JNT

, Volume 90, Issue 3, pp 231-240

Gamma-aminobutyrate aminotransferase activity in brains of schizophrenic patients

  • F. SherifAffiliated withDepartment of Medical Pharmacology, University of Uppsala
  • , L. ErikssonAffiliated withDepartment of Pathology, University of Uppsala
  • , L. OrelandAffiliated withDepartment of Medical Pharmacology, University of Uppsala

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Summary

The activity of gamma-aminobutyrate aminotransferase (GABA-T) was estimated in twelve regions of brains from 22 control subjects and 6 cases with schizophrenia. In the controls, no significant correlation was found between the enzyme activity and age or postmortem interval (PMI) in any of the brain regions studied. In experiments on rat brains, the enzyme activity decreased about 20% during the first 2 hours of storage at room temperature and at 4° C but remained steady thereafter. A similar initial decline in activity in the human brain material cannot be excluded. In the human brains, a slightly lower activity was found in the group below 75 years (n=8) when compared with the group above 75 years (n=8). A tendency to higher activities was found in female brains (n=10) compared with male brains (n=12). No significant difference in the enzyme activity was found between schizophrenic brains, in any of the regions studied, when compared to controls, matched for age, sex and PMI.

Keywords

Aminobutyrate aminotransferase schizophrenia postmortem brain