Antagonism by nialamide of the ethanol-induced locomotor stimulation in mice
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- Ahlenius, S., Brown, R., Engel, J. et al. J. Neural Transmission (1974) 35: 175. doi:10.1007/BF01250743
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Administration of ethanol (2 g/kg, 20% w/v i.p.) to mice produced a significant increase in their locomotor activity. Pretreatment with the monoamine oxidase inhibitor nialamide, whichper se had no marked effect on the locomotor activity, prevented the ethanol-induced locomotor stimulation. The possibility that this effect of nialamide is mediated by a feed-back mechanism is discussed.