The effects of antidepressants on the autonomic nervous system-a current investigation
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Tricyclic antidepressants influence the autonomic nervous system, as is well known; and endogenous depression shows autonomie nervous symptoms besides the readily observable emotional changes. This is a report on a current investigation of the effects of antidepressants on the function of the autonomie nervous system.
In a preliminary study 2 kinds of antidepressants, amitriptyline (tricyclic) and nomifensine (non-tricyclic) were administered to 20 healthy volunteers. The palmar skin potential reflex (SPR), heart rate and respiratory rate were recorded and serum dopamine-β-hydroxylase (DBH) activity was assayed both before and after the administration of antidepressant. The results were as follows:
In the amitriptyline group, the spontaneous SPR and serum DBH activity decreased, and heart rate increased; and the degree of change before and after administration of the drug was statistically significant. Thus amitriptyline seems to suppress the activity of sympathetic nervous system, in addition to suppressing the functioning of the parasympathetic nervous system.
In the nomifensine group, spontaneous SPR and serum DBH activity tended to increase. This seems to indicate that nomifensine suppresses neither the parasympathetic nor the sympathetic nervous functions.
Amitriptyline and nomifensine has different effects on the sympathetic nervous system, suggesting correspondingly divergent pharmacological mechanisms for the depressive modality.
- Forrest, A., Hewett, A., Nicholson, P.: Controlled randomized group comparison of nomifensine and imipramine in depressive illness. British Journal of Clinical Pharmacology (Suppl. 2)4, 215–220 (1977).
- Hoffman, I.: 8-amino-2-menthyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline, a new antidepressant. Arzneimittel-Forschung23, 45–50 (1973).
- Katayama, Y., Yamazaki, K., Nakazawa, T.: Plethysmographic study in the patients with non-specific complaints in the head-cervico-brachial regions: with a special reference to laterality in vasomotor responses and “cervical sympathetic dysharmony”. J. Neural Transm.38, 59–69 (1976).
- McCleary, R. A.: The nature of the galvanic skin response. Psychol. Bull.47, 97–117 (1950)
- Nagatsu, T., Udenfriend, S.: Photometric assay of dopamine-β-hydroxylase in human blood. Clin. Chem.18, 980–981 (1972)
- Wang, G. H.: The galvanic skin reflex. A review of old and recent works from a physiological point of view. Part 1. Amer. J. Physic. Med.36, 295–320 (1957).
- Weinshilboum, R., Axelrod, J.: Serum dopamine-β-hydroxylase activity. Circ. Res.28, 307–308 (1971).
- Weinshilboum, R. M., Thoa, N. B., Johnson, D. G., Axelrod, J.: Proportional release of norepinephrine and dopamine-β-hydroxylase from sympathetic nervous. Science174, 1349–1351 (1971)
- Yamazaki, K.: Habituation of orienting reflex in patients with hyperemotionality. An attempt to discriminate between non-organic and organic disorders by using skin potential reflex. Psychiatria et Neurologia Japonica (Japan)75, 681–697 (1973).
- The effects of antidepressants on the autonomic nervous system-a current investigation
Journal of Neural Transmission
Volume 54, Issue 1-2 , pp 65-73
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Industry Sectors