Journal of Neural Transmission

, Volume 64, Issue 2, pp 113–127

Increased life expectancy resulting from addition of l-deprenyl to Madopar® treatment in Parkinson's disease: A longterm study


  • W. Birkmayer
    • Evangelical Hospital
  • J. Knoll
    • Department of PharmacologySemmelweis University, Medical School
  • P. Riederer
    • Ludwig Boltzmann-Institute of Clinical Neurobiology, Neurochemistry GroupLainz-Hospital
  • M. B. H. Youdim
    • Technion-Faculty of Medicine, Department of PharmacologyRappaport Family Research Institute
  • Vera Hars
    • Department of Clinical Research and BiometricsChinoin Pharmaceutical and Chemical Works, Ltd.
  • J. Marton
    • Department of Clinical Research and BiometricsChinoin Pharmaceutical and Chemical Works, Ltd.
Original Papers

DOI: 10.1007/BF01245973

Cite this article as:
Birkmayer, W., Knoll, J., Riederer, P. et al. J. Neural Transmission (1985) 64: 113. doi:10.1007/BF01245973


In an open, uncontrolled study the longterm (9 years) effect of treatment with Madopar® alone (n=377) or in combination with l-deprenyl (selegiline, selective monoamine oxidase type B inhibitor) (n=564) have been compared in Parkinsonian patients. In patients who lost their response to conventional Madopar therapy the addition of l-deprenyl resulted in a significant recouping of levodopa effect. The survival analysis revealed a significant increase of life expectancy in Madopar-l-deprenyl group regardless of the fact whether or not the significant demographic differences between the two groups were taken into account. Although the mechanism underlying this action of l-deprenyl is not known, the results are interpreted as indicating l-deprenyl's ability to prevent or retard the degeneration of striatal dopaminergic neurons. l-Deprenyl is the first anti-Parkinson drug having such a property. This hypothesis is not far fetched since l-deprenyl selectively prevents the degeneration of striatal dopaminergic neurons induced in animals by the illicit drug l-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Since latter compound is known to cause Parkinsonism in man and primates or Parkinson-like neurochemical and pathological changes in other animals the implications of the present study involving monoamine oxidase activity and l-deprenyl are apparent.

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© Springer-Verlag 1985