Journal of Neural Transmission / General Section JNT

, Volume 91, Issue 2, pp 161–180

A scientific rationale for protective therapy in Parkinson's disease

  • C. W. Olanow
Full Papers

DOI: 10.1007/BF01245230

Cite this article as:
Olanow, C.W. J. Neural Transmission (1993) 91: 161. doi:10.1007/BF01245230

Summary

The desire to introduce neuroprotective therapy for Parkinson's disease has begun to focus attention on pathogenetic mechanisms responsible for cell death. Considerable theory and some evidence have now accumulated to suggest that factors related to oxidative stress, mitochondrial bioenergetic defects, excitatory neurotoxicity, calcium cytotoxicity, and trophic factor deficiencies acting either singularly or in combination may contribute to the development of cell death in Parkinson's disease. A better understanding of the specific pathogenetic mechanism involved in cell degeneration might provide a scientific basis for testing a putative neuroprotective therapy. This chapter reviews the theory and evidence in support of these different mechanisms and possible strategies that might provide neuroprotection and interfere with the natural progression of Parkinson's disease.

Keywords

NeuroprotectionneurodegenerationParkinson's diseaseoxidative stress

Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • C. W. Olanow
    • 1
  1. 1.Department of NeurologyUniversity of South FloridaTampaUSA