Short Communication

Journal of Neural Transmission / General Section JNT

, Volume 93, Issue 1, pp 71-74

Dopamine D2 receptor alteration in patients with periodic movements in sleep (nocturnal myoclonus)

  • J. StaedtAffiliated withDepartment of Psychiatry, Georg August University
  • , G. StoppeAffiliated withDepartment of Psychiatry, Georg August University
  • , A. KöglerAffiliated withDepartment of Nuclear Medicine, Georg August University
  • , D. MunzAffiliated withDepartment of Nuclear Medicine, Georg August University
  • , H. RiemannAffiliated withDepartment of Psychiatry, Georg August University
  • , D. EmrichAffiliated withDepartment of Nuclear Medicine, Georg August University
  • , E. RütherAffiliated withDepartment of Psychiatry, Georg August University

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Summary

Periodic movements in sleep (PMS) can cause severe sleep disturbances. We investigated the central dopamine D2 receptor density in patients with PMS with123I-IBZM and single photon emission tomography (SPET). In PMS there was a lower123I-IBZMbinding in the basal ganglia compared tothe control group. The results indicate a loss of central D2 receptors in PMS.

Keywords

Dopamine receptors octurnal myoclonus PMS SPET