Dopamine D2 receptor alteration in patients with periodic movements in sleep (nocturnal myoclonus)
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- Staedt, J., Stoppe, G., Kögler, A. et al. J. Neural Transmission (1993) 93: 71. doi:10.1007/BF01244940
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Periodic movements in sleep (PMS) can cause severe sleep disturbances. We investigated the central dopamine D2 receptor density in patients with PMS with123I-IBZM and single photon emission tomography (SPET). In PMS there was a lower123I-IBZMbinding in the basal ganglia compared tothe control group. The results indicate a loss of central D2 receptors in PMS.