Journal of Neural Transmission

, Volume 74, Issue 3, pp 199–205

Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain

  • E. Sofic
  • P. Riederer
  • H. Heinsen
  • H. Beckmann
  • G. P. Reynolds
  • G. Hebenstreit
  • M. B. H. Youdim
Short Note

DOI: 10.1007/BF01244786

Cite this article as:
Sofic, E., Riederer, P., Heinsen, H. et al. J. Neural Transmission (1988) 74: 199. doi:10.1007/BF01244786

Summary

Significant differences in the content of iron (III) and total iron were found in post mortem substantia nigra of Parkinson's disease. There was an increase of 176% in the levels of total iron and 255% of iron (III) in the substantia nigra of the parkinsonian patients compared to age matched controls. In the cortex (Brodmann area 21), hippocampus, putamen, and globus pallidus there was no significant difference in the levels of iron (III) and total iron. Thus the changes in total iron, iron (III) and the iron (II)/iron (III) ratio in the parkinsonian substantia nigra are likely to be involved in the pathophysiology and treatment of this disorder.

Keywords

Total ironiron (III)iron (II)iron (II)/iron (III) ratioParkinson's diseaseneurotoxicity

Copyright information

© Springer Verlag 1988

Authors and Affiliations

  • E. Sofic
    • 1
  • P. Riederer
    • 1
  • H. Heinsen
    • 1
  • H. Beckmann
    • 1
  • G. P. Reynolds
    • 2
  • G. Hebenstreit
    • 3
  • M. B. H. Youdim
    • 4
  1. 1.Clinical Neurochemistry, Department of PsychiatryUniversity of WürzburgWürzburgFederal Republic of Germany
  2. 2.Department of PathologyUniversity of NottinghamNottinghamUK
  3. 3.Niederösterreichisches Landeskrankenhaus für Psychiatrie und NeurologieMauer-ÖhligAustria
  4. 4.Department of PharmacologyRappaport Family Research Institute, Faculty of MedicineTechnion, HaifaIsrael