Journal of Neural Transmission

, Volume 67, Issue 3, pp 287-292

First online:

Iron, a new aid in the treatment of Parkinson patients

  • W. BirkmayerAffiliated withEvangelic Hospital
  • , J. G. D. BirkmayerAffiliated withDepartment of Medical Chemistry, University of Graz

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One of the problems in treating Parkinson patients is the so called “off-effect” which occurs after long term treatment with L-DOPA. Off-effects are characterized by severe rigor and akinesia. Increasing dosages of L-DOPA and decarboxylase- or monoaminooxidase-inhibitors do not improve these symptoms. Intravenously applied iron-in form of a ferri-ferro-complex-exhibited a considerable benefit for all patients treated so far. They regained a remarkable mobility. Their disability score dropped from up to 90% down to 30%. The effect of iron is dosage-dependent and lasts 24 to 48 hours.

Key words

Parkinson disease akinesia iron phenylalanine