Journal of Neural Transmission

, Volume 67, Issue 3, pp 275–285

Physostigmine restores3H-acetylcholine efflux from Alzheimer brain slices to normal level

  • Lena Nilsson
  • Agneta Nordberg
  • J. Hardy
  • P. Wester
  • B. Winblad
Short Notes

DOI: 10.1007/BF01243353

Cite this article as:
Nilsson, L., Nordberg, A., Hardy, J. et al. J. Neural Transmission (1986) 67: 275. doi:10.1007/BF01243353
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Summary

A technique was developed, which made it possible to study thein vitro release of3H-acetylcholine (3H-ACh) from human post mortem brain tissue, collected with short post-mortem delay (2,5–22 hours), both from controls and patients with Alzheimer's disease (AD/SDAT). The tritium (3H) release was investigated during potassium stimulation, and AD/SDAT cortical slices were found to release a decreased amount of3H compared to control brain slices. Physostigmine, 10−5 and 10−4 M, has no significant effect on the release of3H from control slices, while physostigmine 10−4 M increased the evoked release from AD/SDAT brain slices over threefold, nearly to the control level.

Key words

Post mortem 3H-acetylcholine release physostigmine 

Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • Lena Nilsson
    • 1
  • Agneta Nordberg
    • 1
  • J. Hardy
    • 2
  • P. Wester
    • 2
  • B. Winblad
    • 3
  1. 1.Department of PharmacologyUniversity of Uppsala, Biomedical CenterUppsalaSweden
  2. 2.Departments of PathologyUniversity of UmeåUmeåSweden
  3. 3.Geriatric MedicineUniversity of UmeåUmeåSweden

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