Original Investigations

Archives of Toxicology

, Volume 54, Issue 4, pp 275-287

A new approach to practical acute toxicity testing

  • Dietrich LorkeAffiliated withInstitut für Toxikologie, Bayer AG

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Abstract

A method for the investigation of the acute toxicity of an unknown chemical substance, with an estimation on the LD50, is described. Using this, it is possible to obtain with 13 experimental animals adequate information on the acute toxicity and on the LD50. This method has no limitations and applies to drugs, agricultural and industrial chemicals. It can be used for every route of administration.

Key words

Acute toxicity LD50 Fewer animals