Somatic Cell and Molecular Genetics

, Volume 17, Issue 6, pp 609–615

The gonadotropin-releasing hormone (Gnrh) gene maps to mouse chromosome 14 and identifies a homologous region on human chromosome 8

  • Penny Williamson
  • Jill Lang
  • Yvonne Boyd
Brief Communication

DOI: 10.1007/BF01233626

Cite this article as:
Williamson, P., Lang, J. & Boyd, Y. Somat Cell Mol Genet (1991) 17: 609. doi:10.1007/BF01233626

Abstract

The murine gonadotropin-releasing hormone (Gnrh) locus has been mapped to mouse chromosome 14 using a mouse × Chinese hamster somatic cell hybrid panel. The equivalent human locus, known as luteinizing hormone-releasing hormone (LHRH), has been previously mapped to 8p21-8p11.2. Four other loci mapping to the human chromosome 8 short arm have been mapped to mouse chromosome 8; two of these (PLAT, GSR) lie proximal toLHRH, and two (LPL, DEF1) lie distal toLHRH. The localization ofGnrh, the murine homolog ofLHRH, to mouse chromosome 14 therefore defines a hitherto unrecognized block of homology between man and mouse. Furthermore, it indicates that the region of homology between the human chromosome 8 short arm and mouse chromosome 8 is composed of two separate blocks.

Copyright information

© Plenum Publishing Corporation 1991

Authors and Affiliations

  • Penny Williamson
    • 1
  • Jill Lang
    • 2
  • Yvonne Boyd
    • 1
  1. 1.Genetics Division (Harwell), MRC Radiobiology UnitChilton, DidcotEngland
  2. 2.Department of Human Anatomyuniversity of OxfordOxfordEngland