Somatic Cell and Molecular Genetics

, Volume 18, Issue 1, pp 97–102

Chromosomal localization of a human cDNA containing a DIDS binding domain and demonstrating high homology to yeast omnipotent suppressor 45

  • Hernan E. Grenett
  • Peter G. Eipers
  • Vincent J. Kidd
  • Pam Bounelis
  • Gerald M. Fuller
Brief Communication

DOI: 10.1007/BF01233452

Cite this article as:
Grenett, H.E., Eipers, P.G., Kidd, V.J. et al. Somat Cell Mol Genet (1992) 18: 97. doi:10.1007/BF01233452

Abstract

We recently have identified a full-length cDNA (TB3-1) from a human adenocarcinoma cell line T84 cDNA library that encodes a 47.8-kDa protein. TB3-1 shares identity with the putative yeast translation termination factor omnipotent suppressor 45. Using human-mouse somatic cell panel analysis, a family of sequences with high homology to the TB3-1 cDNA clone were localized to human chromosomes 5, 6, 7, and X. Southern analysis of a panel of mammalian and chicken genomic DNA demonstrates that TB3-1 is well conserved in higher vertebrates.

Copyright information

© Plenum Publishing Corporation 1992

Authors and Affiliations

  • Hernan E. Grenett
    • 1
  • Peter G. Eipers
    • 2
  • Vincent J. Kidd
    • 3
  • Pam Bounelis
    • 1
  • Gerald M. Fuller
    • 1
  1. 1.Department of Cell BiologyUniversity of Alabama at BirminghamBirmingham
  2. 2.Laboratory of Medical GeneticsUniversity of Alabama at BinninghamBirmingham
  3. 3.Department of Tumor Cell BiologySt. Jude Children's Research HospitalMemphis

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