Brief Communication

Somatic Cell and Molecular Genetics

, Volume 19, Issue 6, pp 571-575

First online:

The UDP-galactose translocator gene is mapped to band Xp11.23-p11.22 containing the Wiskott-Aldrich syndrome locus

  • Takahiko HaraAffiliated withDepartment of Pure and Applied Sciences, College of Arts and Sciences, University of Tokyo
  • , Masatake YamauchiAffiliated withDivision of Genetics, National Institute of Radiological Sciences
  • , Ei-ichi TakahashiAffiliated withDivision of Genetics, National Institute of Radiological Sciences
  • , Masato HoshinoAffiliated withDepartment of Pure and Applied Sciences, College of Arts and Sciences, University of Tokyo
  • , Kazuhisa AokiAffiliated withDepartment of Pure and Applied Sciences, College of Arts and Sciences, University of Tokyo
  • , Dai AyusawaAffiliated withInstitute of Molecular and Cellular Biosciences, University of Tokyo
  • , Masao KawakitaAffiliated withDepartment of Pure and Applied Sciences, College of Arts and Sciences, University of Tokyo

Abstract

We have cloned a segment of the human gene encoding UDP-galactose translocator by genetic complementation of its defective mutant in mouse FM3A cells. Chromosome mapping using fluorescentin situ hybridization revealed that the cloned gene hybridized to the Xp11.23-11.23 region of the X chromosome. This region is shared by the locus of Wiskott-Aldrich syndrome, an X-linked recessive immunodeficiency disorder, characterized by defective sugar chains on cell surface components. Genetic and phenotypic similarities suggest a possible link between UDP-galactose translocator and the Wiskott-Aldrich syndrome (WAS).