Journal of Molecular Evolution

, Volume 41, Issue 3, pp 257–261

Hydrogen bonding in the template-directed oligomerization of a pyrimidine nucleotide analogue

  • M. J. van Vliet
  • J. Visscher
  • Alan W. Schwartz
Articles

DOI: 10.1007/BF01215172

Cite this article as:
van Vliet, M.J., Visscher, J. & Schwartz, A.W. J Mol Evol (1995) 41: 257. doi:10.1007/BF01215172

Abstract

We have studied the oligomerization of an activated, achiral nucleotide analogue related to the pyrimidine barbituric acid in the absence and in the presence of a complementary, pyrophosphate-linked oligomer. Although no template-directed catalysis of the oligomerization was observed with water as solvent, catalysis of the oligomerization was demonstrated in a mixture of dimethylformamide with water. Poly(U) also stimulated the oligomerization, but was less effective than the analogue. Environments in which similar effects may be observed, and some potential implications for prebiotic chemistry, are discussed.

Key words

Nucleotide analoguesOligomerizationPrebiotic chemistryMolecular recognitionSolvent polarityHydrogen bonding

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • M. J. van Vliet
    • 1
  • J. Visscher
    • 1
  • Alan W. Schwartz
    • 1
  1. 1.Evolutionary Biology Research Group, Faculty of ScienceUniversity of NijmegenNijmegenThe Netherlands