Article

Brain Topography

, Volume 9, Issue 2, pp 117-124

First online:

Figures of merit to compare distributed linear inverse solutions

  • Rolando Grave de Peralta MenendezAffiliated withInstitute fur Experimentelle Audiologie, Universitat Munster
  • , Sara L. Gonzalez AndinoAffiliated withInstitute fur Experimentelle Audiologie, Universitat Munster
  • , Bernd LütkenhönerAffiliated withInstitute fur Experimentelle Audiologie, Universitat Munster

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Summary

This paper introduces the concept of the resolution matrix as the basis for an objective theoretical comparison of distributed linear inverse solutions to the neuroelectromagnetic inverse problem. In particular, we describe how figures of merit derived from the resolution matrices can be represented graphically to evaluate merits and shortcomings of the different solutions. The use of the figures of merit is illustrated with two solutions that consider minimal a priori information about the generators: Classical Minimum Norm and Backus Gilbert. We recommend to start any analysis with the individual exploration of the resolution kernel for each grid point or at least for those points where the activity is likely to occur. This analysis might help in selecting the optimal inverse for the sources that are supposed to be active in the process under study.

Key words

Distributed solutions Inverse problem Distributed source models Figures of merit