Journal of Cancer Research and Clinical Oncology

, Volume 121, Issue 3, pp 181–188

Rhythm alteration in patients with metastatic breast cancer and poor prognostic factors

  • Yvan Touitou
  • Francis Lévi
  • André Bogdan
  • Manuel Benavides
  • François Bailleul
  • Jean-Louis Misset
Original Paper

DOI: 10.1007/BF01198101

Cite this article as:
Touitou, Y., Lévi, F., Bogdan, A. et al. J Cancer Res Clin Oncol (1995) 121: 181. doi:10.1007/BF01198101

Abstract

Circulating blood cell counts, serum cortisol, proteins, alkaline phosphatase, carcinoembryonic antigen and CA15.3 displayed significant circadian rhythms in a group of 13 women with metastatic breast cancer. Statistical significance (P<0.05) was assessed with both analysis of variance and cosinor analysis. All patients had been previously treated with chemo-and/or radiotherapy and/or antiestrogens. All patients had been treatment-free for 1 month prior to the study. Each patient had blood drawn every 4 h for 48 h. Circadian rhythms were examined as a function of performance status, graded according to the World Health Organization, liver involvement and number of metastatic sites. Group circadian rhythms in serum cortisol or proteins were abolished in patients with liver metastases, and were altered in cases of poor performance status. Circulating leukocytes, neutrophils or platelets did not exhibit synchronized circadian rhythmicity in patients with poor performance status or liver metastases. The number of metastatic organs had a minor influence on circadian rhythmicity. These results suggest that rhythm alteration may be associated with both poor performance status and liver metastases in patients with advanced breast cancer. Such alteration of the normal circadian time structure may favor and/or result from cancer spread.

Key words

Breast cancerPrognostic factorsCircadian rhythmsCortisolTumor maker antigensBlood white cells

Abbreviation

CEA

Carcinoembryonic antigen

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Yvan Touitou
    • 1
  • Francis Lévi
    • 2
  • André Bogdan
    • 1
  • Manuel Benavides
    • 2
  • François Bailleul
    • 2
  • Jean-Louis Misset
    • 2
  1. 1.Department of BiochemistryFaculté de Médecine Pitié-SalpêtrièreParis Cedex 13France
  2. 2.Laboratoire Rythmes Biologiques et Chronothérapeutique and Service des Maladies Sanguines, Immunitaires et Tumorales, Institut du Cancer et d'ImmunogénétiqueHôpital Paul BrousseVillejuifFrance